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Research into Ampakines

Ampakines may be able to treat cognitive impairment and neurodegeneration. It is also speculated that mental illnesses including depression could someday be treated by ampakines.

Intracranial Pharmacotherapy and Pain Assays in Rodents.

Glyproline Pro-Ampakine with Neuroprotective Activity.

Stargazin differentially modulates ampakine gating kinetics and pharmacology.

Effects of chronic systemic low-impact ampakine treatment on neurotrophin expression in rat brain.

Oncolytic Properties of Ampakines In Vitro.

Ampakines Attenuate Staurosporine-induced Cell Death in Primary Cortical Neurons: Implications in the ‘Chemo-Brain’ Phenomenon.

Tarps differentially affect the pharmacology of ampakines.

The impact and mechanism of a novel allosteric AMPA receptor modulator LCX001 on protection against respiratory depression in rodents.

New AMPA receptor positive modulators for rehabilitation of patients after cerebral accidents.

Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits.

Neuroplasticity Underlying the Comorbidity of Pain and Depression.

Drug repurposing and emerging adjunctive treatments for schizophrenia.

Ampakines Enhance Weak Endogenous Respiratory Drive and Alleviate Apnea in Perinatal Rats.

Cisplatin Causes Mitochondrially Mediated Hippocampal Damage.

Coadministration of the AMPAKINE CX717 with Propofol Reduces Respiratory Depression and Fatal Apneas.

New Therapy for Apnea of Prematurity?

Ampakines stimulate phrenic motor output after cervical spinal cord injury

Spinal delivery of ampakine CX717 impacts phrenic motor output in adult rats

AMPAkines Have Novel Analgesic Properties in Rat Models of Persistent Neuropathic and Inflammatory Pain.

Effects of the putative cognitive-enhancing ampakine, CX717, on attention and object recognition memory.

Ampakines Enhance Respiratory Motor Output In A Murine Model Of Pompe Disease.

Opiate-induced suppression of rat hypoglossal motoneuron activity and its reversal by ampakine therapy.

Ampakines Stimulate Respiratory Motor Output and Ventilation in a Murine Model of Pompe Disease.

Brief ampakine treatments slow the progression of Huntington's disease phenotypes in R6/2 mice.

Delta oscillation and short-term plasticity in the rat medial prefrontal cortex: modelling NMDA hypofunction of schizophrenia.

Performance enhancement at the cost of potential brain plasticity: neural ramifications of nootropic drugs in the healthy developing brain.

Brief ampakine treatments slow the progression of Huntington's disease phenotypes in R6/2 mice.

AMPAKINE enhancement of social interaction in the BTBR mouse model of autism

Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia--sub-chronic and early postnatal PCP treatment in attentional set-shifting.

Pharmacological Enhancement of Memory and Executive Functioning in Laboratory Animals

Ampakine therapy to counter fentanyl-induced respiratory depression.

Ampakine CX717 protects against fentanyl-induced respiratory depression and lethal apnea in rats.

Ampakine (CX717) effects on performance and alertness during simulated night shift work.

Glutamatergic drugs for schizophrenia

Drug offsets sleep deprivation effects, in monkeys

Cosmetic Neurology: For Physicians the Future is Now

Facilitation of task performance and removal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primates

Restoration of long-term potentiation in middle-aged hippocampus after induction of brain-derived neurotrophic factor.

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